OYS Tehohoitokeskus

Tutkimus

Yleistä tutkimushankkeista, jos esitellään kaikki hankkeet yhdellä sivulla.

Critical illness is associated with long-term sequelae regarding quality of life, functional outcome and socioeconomic status
Prospective data collected from the Northern Finland Birth Cohort is used to explore risk factors for hospitalization and intensive care admission during follow -up
Birth cohort includes comprehensive evaluation at the age of 31 performed in 1997
Hopitalizations and intensive care admissions followed until 2020 in this cohort
Results can be used to create models for population based assessment for resource planning and preventive measures to decrease the increasing need for intensive care services

Follow-up of a national cohort of children treated in intensive care due to traumatic brain injury  
Aim is to clarify the long-term health-related quality of life (HRQL), psychological and psychiatric outcome, schooling difficulties, as well as family burden and socioeconomical situation
Data is needed to identify those surviving patients who are at greatest risk for health impairments, and to elucidate the factors affecting their recovery
Results can be used to plan rehabilitation, social and psychiatric interventions beyond the hospital doors to maximize the quality of life of young survivors and their families

Myocardial dysfunction in sepsis is known to be associated with significantly increased short and long-term mortality with no definitive therapeutic option available
Specific cause and mechanisms, diagnostics and classification of myocardial depression in sepsis is unclear
Aim is to study the long term cardiac complications related to sepsis, risk factors for cardiac impairment in sepsis and its pathophysiological mechanisms
Results can be used to improve early detection, treatment and need for cardiac long- term follow-up to improve outcome

 Liberation from intensive care through so called ABCDEF Bundle is used to shift the ICU culture from sedation and restraints to patients who are awake, cognitively engaged, and mobile with family members engaged as partners with the ICU team at the bedside.
With this comprehensive treatment bundle incidence of harmful iatrogenic aspects of care can be decreased (eg. delirium, post- intensive care syndrome) while length of stay and costs decrease
 Hypothesis is that tactile kinesthetic treatment as part of ABCDEF bundle´s delirium prevention, early mobility and exercise features will improve sleep quality and have impact on delirium incidence as well as long-term functional outcome following hospital discharge
The results will help in treatment culture change and in planning resouces needed for implementation

Kyösti E, Ala-Kokko TI, Ohtonen P, Peltoniemi O, Rautiainen P, Kataja J, Ebeling H, Liisanantti JH. Factors associated with health-related quality of life 6 years after ICU discharge in a Finnish paediatric population: a cohort study. Intensive Care Med. 2018;44:1378-1387.
Jansson MM, Syrjälä HP, Talman K, Meriläinen MH, Ala-Kokko TI. Critical care nurses’ knowledge of, adherence to, and barriers toward institution-specific ventilator bundle. Am J Infect Control. 2018;46:1051-1056.
Kyösti E, Ala-Kokko TI, Ohtonen P, Peltoniemi O, Ebeling H, Spalding M, Rautiainen P, Kataja J, Liisanantti JH. Strengths and Difficulties Questionnaire Assessment of Long-Term Psychological Outcome in Children After Intensive Care Admission. Pediatr Crit Care Med. 2019;20:e496-e502.
Kyösti E, Peltoniemi O, Liisanantti JH, Ohtonen P, Ebeling H, Spalding M, Rautiainen P, Kataja J, Ala-Kokko TI. School Performance After Pediatric Intensive Care-Association of Mental Well-Being, Chronic Illnesses, and Family Socioeconomic Status. Pediatr Crit Care Med. 2020; 12:e1099-e1105
Kortelainen J, Ala-Kokko T, Tiainen M, Strbian D, Rantanen K, Laurila J, Koskenkari J, Kallio M, Toppila J, Väyrynen E, Skrifvars MB, Hästbacka. Early recovery of frontal EEG slow wave activity during propofol sedation predicts outcome after cardiac arrest. Resuscitation. 2021;165:170-176

Karhu J, Ala-Kokko TI, Vuorinen T, Ohtonen P, Syrjälä H. Lower respiratory tract virus findings in mechanically ventilated patients with severe community-acquired pneumonia. Clin Infect Dis. 2014 ;59:62-70. 
Erikson K, Liisanantti JH, Hautala N, Koskenkari J, Kamakura R, Herzig KH, Syrjälä H, Ala-Kokko TI. Retinal arterial blood flow and retinal changes in patients with sepsis: preliminary study using fluorescein angiography. Crit Care. 2017 Apr 10;21(1):86.
Kortelainen J, Väyrynen E, Huuskonen U, Laurila J, Koskenkari J, Backman JT, Alahuhta S, Seppänen T, Ala-Kokko T. Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury. Anesthesiology. 2017;126:94-103.
Tuovila M, Erkinaro T, Savolainen ER, Laurila P, Ohtonen P, Ala-Kokko T. The impact of sample site and storage on thromboelastography values. Am J Hematol. 2017;92:E160-E162. 
Karhu J, Ala-Kokko TI, Vuorinen T, Ohtonen P, Julkunen I, Syrjälä HT. Interleukin-5, interleukin-6, interferon induced protein-10, procalcitonin and C-reactive protein among mechanically ventilated severe community-acquired viral and bacterial pneumonia patients. Cytokine. 2019 ;113:272-276.
Erikson K, Tuominen H, Vakkala M, Liisanantti JH, Karttunen T, Syrjälä H, Ala-Kokko TI. Brain tight junction protein expression in sepsis in an autopsy series. Crit Care. 2020 29;24:385.